Maternal Immunization with Influenza or Tetanus Toxoid Vaccine for Passive Antibody Protection in Young Infants
Identifieur interne : 001E73 ( Main/Exploration ); précédent : 001E72; suivant : 001E74Maternal Immunization with Influenza or Tetanus Toxoid Vaccine for Passive Antibody Protection in Young Infants
Auteurs : Janet A. Englund [États-Unis] ; Innocent N. Mbawuike [États-Unis] ; Hunter Hammill [États-Unis] ; Marsha Cline Holleman [États-Unis] ; Barbara D. Baxter [États-Unis] ; W. Paul Glezen [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1993.
Abstract
Women in the last trimester of pregnancy were given trivalent inactivated influenza virus vaccine (TIV; A/Sichuan/H3N2, A/Taiwan/H1N1, B/Victoria) or tetanus toxoid (TT). Maternal blood was drawn before immunization and at delivery (median, 5 weeks later); infant blood was obtained within 5 days of birth and 2 months later. Antibody responses to TIV and TT were determined by microneutralization assay and ELISA. T cell response was determined by lymphocyte proliferation. Maternal seroconversion to vaccine antigens was found to one or more influenza antigen in all TIV recipients and to TT in 9 of 13 TT recipients. Significantly higher IgG antibodies to maternal vaccine antigens were present in cord and infant serum. Significant blastogenic responses were seen to influenza A and Bin maternal cells ofTIV-immunized women but not in cord or infant lymphocytes. Maternal immunization resulted in higher infant levels of vaccine-specific IgG antibody but not in the transfer of specific T lymphocyte response(s) or production of neonatal IgM antibody.
Url:
DOI: 10.1093/infdis/168.3.647
Affiliations:
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Englund</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Janet A. Englund, Dept. of Microbiology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Mbawuike, Innocent N" sort="Mbawuike, Innocent N" uniqKey="Mbawuike I" first="Innocent N." last="Mbawuike">Innocent N. Mbawuike</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hammill, Hunter" sort="Hammill, Hunter" uniqKey="Hammill H" first="Hunter" last="Hammill">Hunter Hammill</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holleman, Marsha Cline" sort="Holleman, Marsha Cline" uniqKey="Holleman M" first="Marsha Cline" last="Holleman">Marsha Cline Holleman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Baxter, Barbara D" sort="Baxter, Barbara D" uniqKey="Baxter B" first="Barbara D." last="Baxter">Barbara D. Baxter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Glezen, W Paul" sort="Glezen, W Paul" uniqKey="Glezen W" first="W. Paul" last="Glezen">W. Paul Glezen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Microbiology and Immunology, Pediatrics, Family Practice, and Obstetrics and Gynecology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1993-09">1993</date><biblScope unit="vol">168</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="647">647</biblScope><biblScope unit="page" to="656">656</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Women in the last trimester of pregnancy were given trivalent inactivated influenza virus vaccine (TIV; A/Sichuan/H3N2, A/Taiwan/H1N1, B/Victoria) or tetanus toxoid (TT). Maternal blood was drawn before immunization and at delivery (median, 5 weeks later); infant blood was obtained within 5 days of birth and 2 months later. Antibody responses to TIV and TT were determined by microneutralization assay and ELISA. T cell response was determined by lymphocyte proliferation. Maternal seroconversion to vaccine antigens was found to one or more influenza antigen in all TIV recipients and to TT in 9 of 13 TT recipients. Significantly higher IgG antibodies to maternal vaccine antigens were present in cord and infant serum. Significant blastogenic responses were seen to influenza A and Bin maternal cells ofTIV-immunized women but not in cord or infant lymphocytes. Maternal immunization resulted in higher infant levels of vaccine-specific IgG antibody but not in the transfer of specific T lymphocyte response(s) or production of neonatal IgM antibody.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Englund, Janet A" sort="Englund, Janet A" uniqKey="Englund J" first="Janet A." last="Englund">Janet A. Englund</name></region><name sortKey="Baxter, Barbara D" sort="Baxter, Barbara D" uniqKey="Baxter B" first="Barbara D." last="Baxter">Barbara D. Baxter</name><name sortKey="Englund, Janet A" sort="Englund, Janet A" uniqKey="Englund J" first="Janet A." last="Englund">Janet A. Englund</name><name sortKey="Glezen, W Paul" sort="Glezen, W Paul" uniqKey="Glezen W" first="W. Paul" last="Glezen">W. Paul Glezen</name><name sortKey="Hammill, Hunter" sort="Hammill, Hunter" uniqKey="Hammill H" first="Hunter" last="Hammill">Hunter Hammill</name><name sortKey="Holleman, Marsha Cline" sort="Holleman, Marsha Cline" uniqKey="Holleman M" first="Marsha Cline" last="Holleman">Marsha Cline Holleman</name><name sortKey="Mbawuike, Innocent N" sort="Mbawuike, Innocent N" uniqKey="Mbawuike I" first="Innocent N." last="Mbawuike">Innocent N. Mbawuike</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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